{"id":39048,"date":"2020-10-22T16:08:56","date_gmt":"2020-10-22T19:08:56","guid":{"rendered":"https:\/\/regiaonews.net.br\/2022\/?p=39048"},"modified":"2020-10-22T16:12:01","modified_gmt":"2020-10-22T19:12:01","slug":"nitazoxanida-reduz-carga-viral-de-pacientes-com-covid-19-diz-pesquisa","status":"publish","type":"post","link":"https:\/\/regiaonews.net.br\/2022\/2020\/10\/22\/nitazoxanida-reduz-carga-viral-de-pacientes-com-covid-19-diz-pesquisa\/","title":{"rendered":"Nitazoxanida reduz carga viral de pacientes com covid-19, diz pesquisa"},"content":{"rendered":"
\"\"<\/a>
(Bras\u00edlia – DF, 19\/10\/2020) Cerim\u00f4nia de An\u00fancio do Resultado do Estudo Cl\u00ednico Covid-19 MCTI.
Foto: Isac N\u00f3brega\/PR<\/figcaption><\/figure>\n

 <\/p>\n

O estudo cl\u00ednico\u00a0sobre\u00a0o uso do medicamento nitazoxanida em pacientes na fase precoce da covid-19 demonstrou efic\u00e1cia no tratamento da doen\u00e7a, reduzindo a carga viral das pessoas infectadas. O an\u00fancio ocorreu durante cerim\u00f4nia no Pal\u00e1cio do Planalto, na tarde desta segunda-feira (19), com a participa\u00e7\u00e3o do presidente Jair Bolsonaro.<\/p>\n

A pesquisa foi iniciada pelo Laborat\u00f3rio Nacional de Bioci\u00eancias, em Campinas (SP), que integra o Centro Nacional de Pesquisa em Energia e Materiais\u00a0(CNPEM, )instituto vinculado ao Minist\u00e9rio da Ci\u00eancia, Tecnologia e Inova\u00e7\u00e3o (MCTI). O laborat\u00f3rio ficou respons\u00e1vel pelos estudos\u00a0in silico\u00a0<\/em>(computadores) e\u00a0in vitro<\/em>\u00a0(laborat\u00f3rio com c\u00e9lulas infectadas). A\u00a0fase de ensaios cl\u00ednicos\u00a0foi responsabilidade de outros centros da Rede Virus, ligada ao MCTI.<\/p>\n

O titular da pasta, ministro Marcos Pontes, celebrou o resultado positivo.\u00a0“O que eu posso dizer \u00e9 que n\u00f3s temos agora um medicamento comprovado cientificamente que \u00e9 capaz de reduzir a carga viral. Com essa redu\u00e7\u00e3o da carga viral, significa que reduz o cont\u00e1gio nas pessoas que tomam o medicamento nos primeiros dias, reduz a capacidade de cont\u00e1gio e diminui a probabilidade dessa pessoa aumentarem os sintomas, ir para o hospital e falecer”, disse.<\/p>\n

O pontap\u00e9 da pesquisa foi dado com a an\u00e1lise de 2 mil drogas, testadas com intelig\u00eancia artificial, para verificar se poderiam inibir os efeitos do v\u00edrus Sars-Cov-2, causador da covid-19 no organismo humano. Os estudos no Laborat\u00f3rio Nacional de Bioci\u00eancias chegaram a cinco drogas, que foram para uma segunda fase, que era o teste\u00a0in vitro\u00a0<\/em>feito com c\u00e9lulas humanas infectadas. Neste teste, o f\u00e1rmaco nitazoxanida, que \u00e9 um verm\u00edfugo muito conhecido no pa\u00eds, apresentou 94% de capacidade de inibir o novo coronav\u00edrus.<\/p>\n

Testes em humanos<\/h2>\n

Foi s\u00f3 ap\u00f3s estas etapas que os testes em humanos foram iniciados, com mais de 1,5 mil pacientes volunt\u00e1rios, que tinham at\u00e9 tr\u00eas dias de sintomas e foram acompanhados em sete diferentes unidades hospitalares do pa\u00eds.<\/p>\n

Nesta fase, de acordo com a coordenadora do estudo cl\u00ednico, Patr\u00edcia Rocco, foram feitos testes duplo cego, quando nem o paciente e nem o m\u00e9dico sabem qual a medica\u00e7\u00e3o est\u00e1 sendo tomada, e randomizados, quando os pacientes s\u00e3o distribu\u00eddos aleatoriamente em dois grupos, um que recebe o medicamento e outro que recebe um placebo. A dose oferecida era de 500 miligramas da nitazoxanida, tr\u00eas vezes ao dia, ou o placebo durante cinco dias.<\/p>\n

“Esses pacientes eram acompanhados de forma remota at\u00e9 sete dias ap\u00f3s a terapia. Constatamos que a nitazoxanida, em compara\u00e7\u00e3o com o placebo, acarretou, ao final da terapia, redu\u00e7\u00e3o significativa da carga viral e um maior n\u00famero de pacientes com resultado negativo para o Sars-Cov-2″, disse a m\u00e9dica, que \u00e9 professora titular e chefe do Laborat\u00f3rio de Investiga\u00e7\u00e3o Pulmonar do Instituto de Biof\u00edsica Carlos Chagas Filho, da Universidade Federal do Rio de Janeiro (UFRJ).<\/p>\n

Segundo Patr\u00edcia, esse resultado \u00e9 de extrema import\u00e2ncia, pois a nitozoxanida \u00e9 um rem\u00e9dio de baixo custo e ampla distribui\u00e7\u00e3o, podendo ser usada de forma oral, e que n\u00e3o precisa de interna\u00e7\u00e3o hospitalar. \u201cNa dose utilizada, n\u00e3o apresentou rea\u00e7\u00f5es adversas graves. A redu\u00e7\u00e3o da carga viral implica em menor gravidade, em menor transmissibilidade do v\u00edrus”, disse Patr\u00edcia. A pesquisadora ressaltou que o estudo foi enviado para publica\u00e7\u00e3o em uma revista cient\u00edfica internacional e dever\u00e1 ser revisado por outros cientistas.<\/p>\n

N\u00e3o \u00e9 profil\u00e1tico<\/h2>\n

O ministro Marcos Pontes disse, durante seu discurso, que o medicamento n\u00e3o pode ser usado por quem n\u00e3o apresenta sintomas da doen\u00e7a, mas apenas para pessoas na fase inicial da infec\u00e7\u00e3o. “N\u00e3o \u00e9 profil\u00e1tico, n\u00e3o \u00e9 para preven\u00e7\u00e3o. \u00c9 s\u00f3 depois da detec\u00e7\u00e3o do v\u00edrus”, disse.<\/p>\n

O presidente Jair Bolsonaro tamb\u00e9m comemorou o resultado da pesquisa e destacou a efic\u00e1cia da nitazoxanida no tratamento da covid-19.<\/p>\n

“Atrav\u00e9s das observa\u00e7\u00f5es, atrav\u00e9s de pessoas que concretamente usaram esse medicamento e foi constatado, na ponta da linha, que a carga viral diminu\u00eda. E dessas pessoas que usaram esse medicamento, nenhuma delas sequer foi hospitalizada”, afirmou.<\/p>\n

Vacina obrigat\u00f3ria<\/h2>\n

Ainda durante a cerim\u00f4nia, o presidente voltou a dizer que a vacina contra a covid-19 n\u00e3o ser\u00e1 obrigat\u00f3ria no Brasil. Bolsonaro afirmou que cabe ao Minist\u00e9rio da Sa\u00fade definir as normas do Programa Nacional de Imuniza\u00e7\u00e3o.<\/p>\n

“Tem uma lei de 1975 que diz que cabe ao Minist\u00e9rio da Sa\u00fade o Programa Nacional de Imuniza\u00e7\u00e3o, ali inclu\u00eddas poss\u00edveis vacinas obrigat\u00f3rias. A vacina contra a Covid, como cabe ao Minist\u00e9rio da Sa\u00fade definir esta quest\u00e3o, ela n\u00e3o ser\u00e1 obrigat\u00f3ria”, disse. O presidente tamb\u00e9m afirmou que qualquer vacina contra o v\u00edrus ter\u00e1 que ter sua efic\u00e1cia cient\u00edfica comprovada e ser autorizada previamente pela Ag\u00eancia Nacional de Vigil\u00e2ncia Sanit\u00e1ria (Anvisa).<\/p>\n

*mat\u00e9ria atualizada \u00e0s 9h02 do dia 20\/10 para esclarecimento de informa\u00e7\u00f5es sobre os testes realizados pelo Laborat\u00f3rio Nacional de Bioci\u00eancias<\/em><\/p>\n

fonte : ag\u00eancia Brasil<\/p>\n","protected":false},"excerpt":{"rendered":"

  O estudo cl\u00ednico\u00a0sobre\u00a0o uso do medicamento nitazoxanida em pacientes<\/p>\n","protected":false},"author":2,"featured_media":39049,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[24,25],"tags":[],"class_list":["post-39048","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-brasil","category-cidades"],"yoast_head":"\nNitazoxanida reduz carga viral de pacientes com covid-19, diz pesquisa - Regi\u00e3o News<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/regiaonews.net.br\/2022\/2020\/10\/22\/nitazoxanida-reduz-carga-viral-de-pacientes-com-covid-19-diz-pesquisa\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nitazoxanida reduz carga viral de pacientes com covid-19, diz pesquisa - 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